Panama

David is Panama’s second-largest city and the capital of Chiriquí Province. It's more a center of agricultural industry than a cultural hub. Yet with foreign capital flowing into Chiriquí, David is rapidly gaining wealth and importance, and is poised to boom.

Among Central America's top surf spots, Santa Catalina is still somewhat remote with limited development and home to some seriously wicked surf. Life here is pretty tranquil, in a fishing village where skateboards rip down main street and kids go barefoot but clothing is required to walk to and from the beach. Most non-surfers discover the area as the main springboard for day and overnight trips to Isla de Coiba and its national park, where there's outstanding scuba diving and snorkeling.

Colón Province is much, much more than its run-down capital. Think pristine beaches and lowland rainforests, colonial splendor and the modern engineering marvel of the Panama Canal. Portobelo, with its growing music and art scene, shows the best of the rich culture of the Congos, descendants of enslaved Africans who have preserved the legacy of their ancestors, while the train trip between Panama City and Colón remains one of the greatest rail journeys in the Americas.

One of the world’s richest biomes is the 2240-sq-mile (5790-sq-km) Parque Nacional Darién, where the primeval meets the present with scenery nearly unaltered from one million years ago. Even today in the Darién, the Emberá and Wounaan people maintain many of their traditional practices and retain generations-old knowledge of the rainforest. 

Although it’s just a 10-minute boat ride from the town of Bocas del Toro, Isla Bastimentos is like a different world. Some travelers say this is their favorite island in their favorite part of Panama. The northwest coast of the island is home to palm-fringed beaches that serve as nesting grounds for sea turtles, while most of the northern and southern coasts consist of mangrove islands and coral reefs that lie within the boundaries of the Parque Nacional Marino Isla Bastimentos.

Officially known as El Valle de Antón, this picturesque town is nestled in the crater of a huge extinct volcano, and ringed by verdant forests and jagged peaks. El Valle is a popular weekend getaway for urban dwellers in need of fresh air and scenery and is also a retirement community for foreigners, with some 200 resident expats from more than 40 countries. With an extensive network of trails, this is a superb place for walking, hiking or horseback riding. Nearby forests offer excellent birdwatching, and the valleys of El Valle are home to an impressive set of waterfalls and natural pools.

With white sand and waving palms, the islands of the turquoise Archipiélago de San Blas of the Comarca de Guna Yala are a vision of paradise. This is home to the Guna people, the first indigenous group in Latin America to gain autonomy. Though they have had contact with Europeans since Columbus sailed these waters in 1502, traditional identity and way of life remain paramount.

Colorful and full of Caribbean-style clapboard houses, Bocas del Toro (better known simply as Bocas town) was built by the United Fruit Company in the early 20th century. Today it is a relaxed community of West Indians, Latinos and resident gringos, with a friendly atmosphere that is contagious. It’s an easy place to adapt to and even easier to linger in.

Cherished as Panama's cultural heart and soul, the Península de Azuero is a farming and ranching hub. The area's rolling hills are matched by a long and lovely coastline. Over time the peninsula has seen stark transformations – from verdant rainforest to cattle country, from indigenous land to Spanish stronghold and, finally, from a quiet town to surf central and one of Panama’s travel hot spots.

The archipelago’s most developed island is home to the provincial capital of Bocas del Toro. From the mid-1990s, foreign investors flooded the island, creating hotels, restaurants and condos while infrastructure for water, trash and sewage lagged far behind. Today the island, which runs on diesel, struggles to find a balance between satisfying development and serving community needs.