Santa Cruz fits the typically dual nature of the Atitlán villages, comprising both a waterfront resort (home of the lake's scuba-diving outfit) and an indigenous Kaqchiquel village. The village is about 0.35 miles (600m) uphill from the dock (there are tuk-tuks if you don't fancy the stiff walk). It's a lovely spot, with relaxing accommodations, activities on the water and a complete lack of hustle.
Spreading onto a peninsula at the base of the volcano of the same name, San Pedro remains among the most visited of the lakeside villages – due as much to its reasonably priced accommodations and global social scene as to its spectacular setting. It's a backpacker haven – travelers tend to dig in here for a spell, in pursuit of (in no particular order) drinking, fire-twirling, African drumming, Spanish classes, volcano hiking, hot-tub soaking, partying and hammock swinging.
Santiago Atitlán is the largest of the lake communities, with a strong indigenous identity. Many atitecos (as its people are known) proudly adhere to a traditional Tz'utujil Maya lifestyle. Women wear purple-striped skirts and huipiles embroidered with colored birds and flowers, while older men still wear lavender or maroon striped embroidered pants. The town's cofradías (brotherhoods) maintain the syncretic traditions and rituals of Maya Catholicism. There's a large arts and crafts scene here too. Boatbuilding is a local industry, and rows of rough-hewn cayucos (dugout canoes) are lined up along the shore. The liveliest days to visit are Friday and Sunday, the main market days, but any day will do.
The highlands – El Altiplano – stretch from Antigua to the Mexican border; they comprise Guatemala's most breathtaking region by some degree. Maya identity is stronger here than anywhere in the country and over a dozen distinct groups dwell within the region, each with its own language and clothing. Indigenous tradition blends most tantalizingly with Spanish, and it is common to see Maya rituals taking place in front of and inside colonial churches.
The mountainous departments of Quetzaltenango, Totonicapán and Huehuetenango are generally less visited by tourists than regions closer to Guatemala City. But with extraordinarily dramatic scenery and vibrant indigenous culture, this part of the country presents an invariably fascinating panorama. Highlights of any visit include Quetzaltenango ('Xela' for short), Guatemala's second-largest city, with an ever-growing language school and volunteer work scene; the nearby town of Zunil, with its volcanically heated springs and Maya deity; ascents of the volcanoes around Quetzaltenango; and the remote mountain enclave of Todos Santos Cuchumatán, north of Huehuetenango, with a strong traditional culture and excellent walking possibilities.
With its pastel houses cascading down from a central plaza to the emerald waters of Lago de Petén Itzá, the island town of Flores evokes Venice or somewhere Mediterranean. A 0.3-mile (500m) causeway connects Flores to its humbler sister town of Santa Elena on the mainland, which then merges into the community of San Benito to the west. The three towns actually form one large settlement, often referred to simply as Flores.
Stretching from the steamy lowland forests of El Petén to the dry tropics of the Río Motagua valley, and from the edge of the Western Highlands to the Caribbean Sea, this is Guatemala's most diverse region.
Antigua's beguiling beauty starts to seduce the moment you arrive. Once capital of Guatemala, its streetscapes of pastel facades unfold beneath the gaze of three volcanoes, and meticulously restored colonial buildings sit next to picturesque ruins in park-like surroundings. The city's World Heritage–listed status means that even fast-food chains have to hide themselves behind traditional building facades.
Lívingston is unlike anywhere else in Guatemala. Its Garifuna people, their colors, culture, rhythms, flavors, and disposition, are the best reason to visit – nowhere else in Guatemala will you find such a fun and relaxed vibe. But it's not just the people: good beaches are nearby and the slow-and-easy take on life is enchanting. Here boats lie derelict in picturesque decay; people paddleboard or kayak lazily amid refreshing ocean breezes; and pelicans soar overhead as happy hour starts in late afternoon. It's just lovely.
This region is an interesting mix of local villages, often with little Spanish spoken in favor of Indigenous languages, larger cities and some truly top-notch tourist attractions. It can be beastly hot at times, particularly just before the rainy season from February to May. Oddly, this is when some of the sights are best visited, as they are most known for swimming, spelunking, or getting wet and muddy.