The highlands – El Altiplano – stretch from Antigua to the Mexican border; they comprise Guatemala's most breathtaking region by some degree. Maya identity is stronger here than anywhere in the country and over a dozen distinct groups dwell within the region, each with its own language and clothing. Indigenous tradition blends most tantalizingly with Spanish, and it is common to see Maya rituals taking place in front of and inside colonial churches.
Santa Cruz fits the typically dual nature of the Atitlán villages, comprising both a waterfront resort (home of the lake's scuba-diving outfit) and an indigenous Kaqchiquel village. The village is about 0.35 miles (600m) uphill from the dock (there are tuk-tuks if you don't fancy the stiff walk). It's a lovely spot, with relaxing accommodations, activities on the water and a complete lack of hustle.
Depending on who you talk to, Guatemala City (or Guate as it's also known) is either big, dirty, dangerous and utterly forgettable, or big, dirty, dangerous and utterly fascinating. Either way, there's no doubt there's an energy here unlike anywhere else in Guatemala. It's a place where dilapidated buses belch fumes next to BMWs and Hummers, and where skyscrapers drop shadows on shantytowns.
The mountainous departments of Quetzaltenango, Totonicapán and Huehuetenango are generally less visited by tourists than regions closer to Guatemala City. But with extraordinarily dramatic scenery and vibrant indigenous culture, this part of the country presents an invariably fascinating panorama. Highlights of any visit include Quetzaltenango ('Xela' for short), Guatemala's second-largest city, with an ever-growing language school and volunteer work scene; the nearby town of Zunil, with its volcanically heated springs and Maya deity; ascents of the volcanoes around Quetzaltenango; and the remote mountain enclave of Todos Santos Cuchumatán, north of Huehuetenango, with a strong traditional culture and excellent walking possibilities.
Surrounded by valleys with mountains serrating the horizons, Chichicastenango can seem a world away from the rest of Guatemala. When its narrow cobbled streets and red-tiled roofs are enveloped in mist, it's downright magical. The crowds of crafts vendors and tour groups who flock in for the huge Thursday and Sunday markets lend it a lively commercial atmosphere. Masheños (citizens of Chichicastenango) adhere strongly to Indigenous religions and ceremonies, and the town's various cofradías (religious brotherhoods) hold processions in observance of their saints around the church of Santo Tomás.
Quetzaltenango is Guatemala's second city. It has a great atmosphere – not too big, not too small, enough foreigners to support a good range of hotels and restaurants, but not so many that it loses its national flavor. The city center has an interesting mix of architectural styles – once the Spanish moved out, the Germans moved in and their architecture gives the zone a somber, even Gothic, feel.
This region is an interesting mix of local villages, often with little Spanish spoken in favor of Indigenous languages, larger cities and some truly top-notch tourist attractions. It can be beastly hot at times, particularly just before the rainy season from February to May. Oddly, this is when some of the sights are best visited, as they are most known for swimming, spelunking, or getting wet and muddy.
Separated from the highlands by a chain of volcanoes, the flatlands that run down to the Pacific are universally known as La Costa. It's a sultry region – hot and wet or hot and dry, depending on the time of year – with rich volcanic soil good for growing coffee, palm-oil seeds and sugarcane.
San Juan La Laguna is just 1.2 miles (2km) west by road from busy San Pedro, on a rise above a spectacular bay, but this neat, mellow village has escaped many of the excesses of its neighbor, and some travelers find it a more tranquil setting in which to study Spanish or experience local life. San Juan is special: the Tz'utujil inhabitants take pride in their craft traditions – particularly painting and weaving – and have developed their own tourism infrastructure to highlight their culture to outsiders.
The coastal area around Monterrico is a totally different Guatemala. Life here is steeped with a sultry, tropical flavor, with rustic wooden-slat and thatched-roof architecture and awesome volcanoes that shimmer in the hinterland. It's fast becoming popular with foreigners as a beach break from Antigua or Guatemala City. On weekdays it's relatively quiet, but on weekends and holidays it teems with Guatemalan families.