Quetzaltenango is Guatemala's second city. It has a great atmosphere – not too big, not too small, enough foreigners to support a good range of hotels and restaurants, but not so many that it loses its national flavor. The city center has an interesting mix of architectural styles – once the Spanish moved out, the Germans moved in and their architecture gives the zone a somber, even Gothic, feel.
Surrounded by valleys with mountains serrating the horizons, Chichicastenango can seem a world away from the rest of Guatemala. When its narrow cobbled streets and red-tiled roofs are enveloped in mist, it's downright magical. The crowds of crafts vendors and tour groups who flock in for the huge Thursday and Sunday markets lend it a lively commercial atmosphere. Masheños (citizens of Chichicastenango) adhere strongly to Indigenous religions and ceremonies, and the town's various cofradías (religious brotherhoods) hold processions in observance of their saints around the church of Santo Tomás.
Depending on who you talk to, Guatemala City (or Guate as it's also known) is either big, dirty, dangerous and utterly forgettable, or big, dirty, dangerous and utterly fascinating. Either way, there's no doubt there's an energy here unlike anywhere else in Guatemala. It's a place where dilapidated buses belch fumes next to BMWs and Hummers, and where skyscrapers drop shadows on shantytowns.
The highlands – El Altiplano – stretch from Antigua to the Mexican border; they comprise Guatemala's most breathtaking region by some degree. Maya identity is stronger here than anywhere in the country and over a dozen distinct groups dwell within the region, each with its own language and clothing. Indigenous tradition blends most tantalizingly with Spanish, and it is common to see Maya rituals taking place in front of and inside colonial churches.
San Juan La Laguna is just 1.2 miles (2km) west by road from busy San Pedro, on a rise above a spectacular bay, but this neat, mellow village has escaped many of the excesses of its neighbor, and some travelers find it a more tranquil setting in which to study Spanish or experience local life. San Juan is special: the Tz'utujil inhabitants take pride in their craft traditions – particularly painting and weaving – and have developed their own tourism infrastructure to highlight their culture to outsiders.
The coastal area around Monterrico is a totally different Guatemala. Life here is steeped with a sultry, tropical flavor, with rustic wooden-slat and thatched-roof architecture and awesome volcanoes that shimmer in the hinterland. It's fast becoming popular with foreigners as a beach break from Antigua or Guatemala City. On weekdays it's relatively quiet, but on weekends and holidays it teems with Guatemalan families.
Lívingston is unlike anywhere else in Guatemala. Its Garifuna people, their colors, culture, rhythms, flavors, and disposition, are the best reason to visit – nowhere else in Guatemala will you find such a fun and relaxed vibe. But it's not just the people: good beaches are nearby and the slow-and-easy take on life is enchanting. Here boats lie derelict in picturesque decay; people paddleboard or kayak lazily amid refreshing ocean breezes; and pelicans soar overhead as happy hour starts in late afternoon. It's just lovely.
One of the prettiest of the lakeside villages, San Marcos La Laguna lives a double life. The mostly Maya community occupies the higher ground, while expats and visitors cover a flat jungly patch toward the shoreline with paths snaking through banana, coffee and avocado trees. The two converge under the spreading matapalo (strangler fig) tree of the central plaza.
Antigua's beguiling beauty starts to seduce the moment you arrive. Once capital of Guatemala, its streetscapes of pastel facades unfold beneath the gaze of three volcanoes, and meticulously restored colonial buildings sit next to picturesque ruins in park-like surroundings. The city's World Heritage–listed status means that even fast-food chains have to hide themselves behind traditional building facades.
Spreading onto a peninsula at the base of the volcano of the same name, San Pedro remains among the most visited of the lakeside villages – due as much to its reasonably priced accommodations and global social scene as to its spectacular setting. It's a backpacker haven – travelers tend to dig in here for a spell, in pursuit of (in no particular order) drinking, fire-twirling, African drumming, Spanish classes, volcano hiking, hot-tub soaking, partying and hammock swinging.