Vast, sparsely populated and jungle-covered, Guatemala's largest and northernmost department is a wonderland of exploration. Whether it's the spectacular architectural achievements of the Classic Maya, the bounty of the forest or the chance to lounge lakeside that inspires you, it's all here in abundance.
Separated from the highlands by a chain of volcanoes, the flatlands that run down to the Pacific are universally known as La Costa. It's a sultry region – hot and wet or hot and dry, depending on the time of year – with rich volcanic soil good for growing coffee, palm-oil seeds and sugarcane.
Stretching from the steamy lowland forests of El Petén to the dry tropics of the Río Motagua valley, and from the edge of the Western Highlands to the Caribbean Sea, this is Guatemala's most diverse region.
Depending on who you talk to, Guatemala City (or Guate as it's also known) is either big, dirty, dangerous and utterly forgettable, or big, dirty, dangerous and utterly fascinating. Either way, there's no doubt there's an energy here unlike anywhere else in Guatemala. It's a place where dilapidated buses belch fumes next to BMWs and Hummers, and where skyscrapers drop shadows on shantytowns.
Quetzaltenango is Guatemala's second city. It has a great atmosphere – not too big, not too small, enough foreigners to support a good range of hotels and restaurants, but not so many that it loses its national flavor. The city center has an interesting mix of architectural styles – once the Spanish moved out, the Germans moved in and their architecture gives the zone a somber, even Gothic, feel.
Once a spot that tourists passed through, Cobán has become a destination in its own right and one of the best in the area (outside Guatemala City) for decent food, a range of hotels and activities. For tourists it remains a great hub for taking in the surrounding natural wonders – such as Semuc Champey – in a series of day trips.
The busiest and most built-up lakeside town, Panajachel ('Pana') is the gateway to Lago de Atitlán for most travelers. Strolling the main street, Calle Santander – crammed with travel agencies, handicraft hawkers and rowdy bars, dodging tuk-tuks all the way – you may be forgiven for supposing this paradise lost.
Quiché is the homeland of the K'iche' people, though other groups form the fabric of this culturally diverse region, most notably the Ixil of the eastern Cuchumatanes mountains. Most visitors who come to this largely forgotten pocket of the country are on a jaunt to the famous market at Chichicastenango. Similarly captivating commerce is conducted in the less trammeled territory of Santa Cruz del Quiché, the departmental capital to the north. On its outskirts lie the mysterious ruins of K'umarcaaj, the last capital city of the K'iche'. Adventurous souls push further north for Nebaj, heart of the culturally vibrant Ixil Triangle, with myriad hiking opportunities.
The highlands – El Altiplano – stretch from Antigua to the Mexican border; they comprise Guatemala's most breathtaking region by some degree. Maya identity is stronger here than anywhere in the country and over a dozen distinct groups dwell within the region, each with its own language and clothing. Indigenous tradition blends most tantalizingly with Spanish, and it is common to see Maya rituals taking place in front of and inside colonial churches.
Santa Cruz fits the typically dual nature of the Atitlán villages, comprising both a waterfront resort (home of the lake's scuba-diving outfit) and an indigenous Kaqchiquel village. The village is about 0.35 miles (600m) uphill from the dock (there are tuk-tuks if you don't fancy the stiff walk). It's a lovely spot, with relaxing accommodations, activities on the water and a complete lack of hustle.