Depending on who you talk to, Guatemala City (or Guate as it's also known) is either big, dirty, dangerous and utterly forgettable, or big, dirty, dangerous and utterly fascinating. Either way, there's no doubt there's an energy here unlike anywhere else in Guatemala. It's a place where dilapidated buses belch fumes next to BMWs and Hummers, and where skyscrapers drop shadows on shantytowns.
This region is an interesting mix of local villages, often with little Spanish spoken in favor of Indigenous languages, larger cities and some truly top-notch tourist attractions. It can be beastly hot at times, particularly just before the rainy season from February to May. Oddly, this is when some of the sights are best visited, as they are most known for swimming, spelunking, or getting wet and muddy.
The busiest and most built-up lakeside town, Panajachel ('Pana') is the gateway to Lago de Atitlán for most travelers. Strolling the main street, Calle Santander – crammed with travel agencies, handicraft hawkers and rowdy bars, dodging tuk-tuks all the way – you may be forgiven for supposing this paradise lost.
Antigua's beguiling beauty starts to seduce the moment you arrive. Once capital of Guatemala, its streetscapes of pastel facades unfold beneath the gaze of three volcanoes, and meticulously restored colonial buildings sit next to picturesque ruins in park-like surroundings. The city's World Heritage–listed status means that even fast-food chains have to hide themselves behind traditional building facades.
Vast, sparsely populated and jungle-covered, Guatemala's largest and northernmost department is a wonderland of exploration. Whether it's the spectacular architectural achievements of the Classic Maya, the bounty of the forest or the chance to lounge lakeside that inspires you, it's all here in abundance.
Quetzaltenango is Guatemala's second city. It has a great atmosphere – not too big, not too small, enough foreigners to support a good range of hotels and restaurants, but not so many that it loses its national flavor. The city center has an interesting mix of architectural styles – once the Spanish moved out, the Germans moved in and their architecture gives the zone a somber, even Gothic, feel.
With its pastel houses cascading down from a central plaza to the emerald waters of Lago de Petén Itzá, the island town of Flores evokes Venice or somewhere Mediterranean. A 0.3-mile (500m) causeway connects Flores to its humbler sister town of Santa Elena on the mainland, which then merges into the community of San Benito to the west. The three towns actually form one large settlement, often referred to simply as Flores.
The highlands – El Altiplano – stretch from Antigua to the Mexican border; they comprise Guatemala's most breathtaking region by some degree. Maya identity is stronger here than anywhere in the country and over a dozen distinct groups dwell within the region, each with its own language and clothing. Indigenous tradition blends most tantalizingly with Spanish, and it is common to see Maya rituals taking place in front of and inside colonial churches.
The mountainous departments of Quetzaltenango, Totonicapán and Huehuetenango are generally less visited by tourists than regions closer to Guatemala City. But with extraordinarily dramatic scenery and vibrant indigenous culture, this part of the country presents an invariably fascinating panorama. Highlights of any visit include Quetzaltenango ('Xela' for short), Guatemala's second-largest city, with an ever-growing language school and volunteer work scene; the nearby town of Zunil, with its volcanically heated springs and Maya deity; ascents of the volcanoes around Quetzaltenango; and the remote mountain enclave of Todos Santos Cuchumatán, north of Huehuetenango, with a strong traditional culture and excellent walking possibilities.
Spreading onto a peninsula at the base of the volcano of the same name, San Pedro remains among the most visited of the lakeside villages – due as much to its reasonably priced accommodations and global social scene as to its spectacular setting. It's a backpacker haven – travelers tend to dig in here for a spell, in pursuit of (in no particular order) drinking, fire-twirling, African drumming, Spanish classes, volcano hiking, hot-tub soaking, partying and hammock swinging.