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The epicentre of the Mekong Delta, Can Tho is the largest city in the region and feels like a metropolis after a few days exploring the backwaters. As the political, economic, cultural and transportation centre of the Mekong Delta, it’s a buzzing town with a lively waterfront lined with sculpted gardens, an appealing blend of narrow backstreets and wide boulevards, and perhaps the greatest concentration of foreigners in the delta. It is also the perfect base for nearby floating markets, the major draw for tourists who come here to boat along the many canals and rivers leading out of town.

Fringed with white-sand beaches and with large tracts still cloaked in dense tropical jungle, Phu Quoc rapidly morphed from a sleepy island backwater to a must-visit beach escape for Western expats and sun-seeking tourists. Beyond the resorts lining Long Beach, rapid development beginning on the east coast and mega resorts in sight of Sao Beach, there's still ample room for exploration and escaping the sometimes littered waters. Dive the reefs, kayak in the bays, eat up the back-road kilometres on a motorbike or just lounge on the beach, followed by a massage and a fresh seafood dinner.

Welcome to an alternative reality populated by European royalty, film stars and the otherwise rich and secretive. For the average punter not able to afford an uber-luxurious hotel, this place doesn’t exist. Well, at least not before 2017, when the mother-of-all flashpacker retreats opened here on a private bay.

Highlights of the Danang region include the city's impressive urban energy, the rapidly evolving beach scene to the east of the river, and more remote and spectacular coastal scenery of the nearby Son Tra Peninsula. Look forward to some of Vietnam's best seafood and street food. It's worth booking a walking tour with a local to best understand Danang.

Dalat is an alternative Vietnam: the weather is spring-like instead of tropical hot, the town is dotted with French-colonial villas rather than socialist architecture, and the surrounding farms cultivate strawberries, coffee and flowers instead of rice.

Tra Vinh, one of the prettiest towns in the Mekong Delta, is a peaceful place to explore the region's little-touted Cambodian connection. Around 300,000 ethnic Khmer live in the surrounding province and the area is dotted with more than 140 Khmer pagodas. With wide boulevards shaded by lines of trees, the town itself is more symbolic of the French colonialist era, but get beyond the outskirts and you'll soon discover that Khmer culture is still alive and well in these parts of Vietnam. Tra Vinh also has a small but active Chinese community, one of the few such communities that remain in the Mekong Delta region.

The ‘rice bowl’ of Vietnam, the delta is carpeted in a dizzying variety of greens. It's a water world that moves to the rhythms of the mighty Mekong, where boats, houses and markets float upon the innumerable rivers, canals and streams that criss-cross the landscape like arteries.

Lang Co is an attractive island-like stretch of palm-shaded white sand, with a turquoise lagoon on one side and 10km of beachfront on the other. As a beach resort it's more geared to Vietnamese day trippers than Western travellers, but if the weather's nice the ocean is certainly inviting (if you stay away from the central section, which could be cleaner). High season is April to July. From late August to November rains are frequent, and from December to March it can get chilly.

Buon Ma Thuot can trace its origins back to a simple rural settlement: the Ede name translates as ‘Thuot’s father’s village’. But Buon Ma Thuot (pronounced ‘boon me tote’) has long outgrown its rustic origins and is now a thoroughly modern, affluent city.

Practically obliterated during the American War, Vinh was rebuilt with East German aid – hence the brutalist concrete architecture dominating downtown. The only reasons to stop here are if you're a Ho Chi Minh devotee (he was born in a nearby village), or if you're heading to Laos.