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Graceful, historic Hoi An is Vietnam’s most atmospheric and delightful town. Once a major port, it boasts the grand architecture and beguiling riverside setting that befits its heritage, and the 21st-century curses of traffic and pollution are almost entirely absent.

Nowhere in Vietnam is changing as fast as Danang. For decades it had a reputation as a quiet provincial town, but big changes are ongoing. Stroll along the Han riverfront and you'll find gleaming new modernist hotels, and apartments and restaurants are emerging. Spectacular bridges now span the river, and in the north of the city, the landmark new D-City is rising from the flatlands. Venture south and the entire Danang Beach strip is booming with hotel and resort developments.

A popular weekend escape from HCMC, Vung Tau rocks at weekends when beach-starved locals and expats descend in numbers, but it is relatively quiet during the week. The city enjoys a spectacular location on a peninsula, with ocean on three sides; the light and sea air make it a refreshing break from sultry Saigon.

Set in an idyllic valley, hemmed in by hills, the Mai Chau area is a world away from Hanoi's hustle. The small town of Mai Chau itself is unappealing, but just outside the patchwork of rice fields rolls out, speckled by tiny Thai villages where visitors doss down for the night in traditional stilt houses and wake up to a rural soundtrack defined by gurgling irrigation streams and birdsong.

A large, prosperous coastal city, Quy Nhon (pronounced ‘hwee ngon’) boasts a terrific beach-blessed shoreline and grand boulevards. Its seaside appeal and tidy, litter-free streets make it the kind of place that affluent Vietnamese couples choose to retire to, spending their final days ocean-gazing and promenade-walking.

A French-era hill station, this national park reaches a peak of 1450m at Bach Ma mountain, only 18km from the coast. The cool climate attracted the French, who built over a hundred villas here. Not surprisingly the Viet Minh tried hard to spoil the holiday – the area saw some heavy fighting in the early 1950s and again during the American War.

Once upon a time, Mui Ne was an isolated stretch of shoreline where pioneering travellers camped on the sand. Times have changed and it's now a string of beach resorts, which have fused into one long coastal strip. These resorts are, for the most part, mercifully low-rise and set amid pretty gardens by the sea. The original fishing village is still here, but tourists outnumber locals these days. There are a handful of luxury hotels (and a smattering of cheap guesthouses) but Mui Ne is mainly a midrange resort.

Ha Tien may be part of the Mekong Delta, but lying on the Gulf of Thailand it feels a world away from the rice fields and rivers that typify the region. There are dramatic limestone formations peppering the area, which are home to a network of caves, some of which have been turned into temples. Plantations of pepper trees cling to the hillsides. On a clear day, Phu Quoc Island is easily visible to the west.

Tra Vinh, one of the prettiest towns in the Mekong Delta, is a peaceful place to explore the region's little-touted Cambodian connection. Around 300,000 ethnic Khmer live in the surrounding province and the area is dotted with more than 140 Khmer pagodas. With wide boulevards shaded by lines of trees, the town itself is more symbolic of the French colonialist era, but get beyond the outskirts and you'll soon discover that Khmer culture is still alive and well in these parts of Vietnam. Tra Vinh also has a small but active Chinese community, one of the few such communities that remain in the Mekong Delta region.