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The epicentre of the Mekong Delta, Can Tho is the largest city in the region and feels like a metropolis after a few days exploring the backwaters. As the political, economic, cultural and transportation centre of the Mekong Delta, it’s a buzzing town with a lively waterfront lined with sculpted gardens, an appealing blend of narrow backstreets and wide boulevards, and perhaps the greatest concentration of foreigners in the delta. It is also the perfect base for nearby floating markets, the major draw for tourists who come here to boat along the many canals and rivers leading out of town.

Highlights of this area include the vibrant city of Danang, the former imperial capital of Hue, and the very popular but undeniably stunning historic port town of Hoi An. The best beach scenes are at An Bang near Hoi An and Lang Co near Danang, and for nature fans there is good hiking and birdwatching in Bach Ma National Park. Ancient Cham history is fascinating at My Son, and the compelling Demilitarised Zone (DMZ) showcases the poignant and tragic stories of the American War.

A breathtaking cluster of granite islands, set in aquamarine seas around 15km directly offshore from Hoi An, the Cham Islands make a wonderful excursion. The islands were once closed to visitors and under close military supervision, but now day trips, diving or snorkelling the reefs, and even overnight stays, are possible.

The ‘rice bowl’ of Vietnam, the delta is carpeted in a dizzying variety of greens. It's a water world that moves to the rhythms of the mighty Mekong, where boats, houses and markets float upon the innumerable rivers, canals and streams that criss-cross the landscape like arteries.

Around 40km west of Danang lies lush Ba Na. Originally established in 1919 by the French as a hill resort, the 200-odd old villas are now ruined, but the refreshingly cool weather and gorgeous countryside views make it a worthwhile trip from Danang.

This eponymous provincial capital isn't unpleasant; the climate is mild, and winter days can bring a chilly welcome relief from the heat when a thick fog clings to the banks of the Bang Giang River. But you'll most likely use the city as a base to explore rural Cao Bang province, one of the most beautiful regions in Vietnam.

Northern Vietnam's most appealing city has a distinctly laid-back air with its tree-lined boulevards host to a bundle of colonial-era buildings. Caffeine-aficionado heaven, the central area buzzes with dinky cafes where tables spill out onto the pavements – perfect for people watching.

Northeast Vietnam includes Halong Bay, one of the region's biggest draws. Reasons to linger after your boat trip include the lesser-known but stunning Bai Tu Long Bay, the intersection of nature and culture that is Ba Be National Park, the otherworldly karst landscapes outside of Cao Bang and the urban options in Haiphong.

With its river setting and relatively traffic-free streets, relaxed Kon Tum makes a great stop for travelers intent on exploring the surrounding hill-tribe villages, of which there are 700 or so dotting the area – mostly Bahnar, but also Sedang and Jarai. This is a far better base than Pleiku for delving into indigenous culture, and there are a few intriguing sights in Kon Tum itself.

Just off the Danang Beach coastal road, the Marble Mountains (Ngu Hanh Son) consist of five craggy marble outcrops topped with pagodas. Each mountain is named for the natural element it’s said to represent: Thuy Son (Water), Moc Son (Wood), Hoa Son (Fire), Kim Son (Metal or Gold) and Tho Son (Earth). The villages that have sprung up at the base of the mountains specialise in marble sculpture, though they now astutely use marble from China rather than hacking away at the mountains that bring the visitors in.