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Ha Giang is the final frontier in northern Vietnam, an amazing landscape of limestone pinnacles and granite outcrops. The far north of the province has some of the most spectacular scenery in the country – if not the region – and the trip between Yen Minh and Dong Van, and then across the Mai Pi Leng Pass to Meo Vac, is quite mind-blowing. Ha Giang should be one of the most popular destinations in this region, but its distance from just about everywhere else keeps visitor numbers at a low level.

Few parts of Vietnam stir the imagination with the lure of adventure quite like the highlands. The ribbon that is the Ho Chi Minh Hwy winds its scenic way past coffee plantations, pine-studded mountains, rice paddies with their wallowing buffalo, enormous reed-covered lakes and peaceful villages, laying down the challenge of a two-wheeled journey.

Lang Co is an attractive island-like stretch of palm-shaded white sand, with a turquoise lagoon on one side and 10km of beachfront on the other. As a beach resort it's more geared to Vietnamese day trippers than Western travellers, but if the weather's nice the ocean is certainly inviting (if you stay away from the central section, which could be cleaner). High season is April to July. From late August to November rains are frequent, and from December to March it can get chilly.

Draped along the banks of the Hau Giang River (Bassac River), Chau Doc sees plenty of travelers washing through on the river route between Cambodia and Vietnam. A likeable little town with significant Chinese, Cham and Khmer communities, Chau Doc's cultural diversity – apparent in the mosques, temples, churches and nearby pilgrimage sites – makes it fascinating to explore even if you're not Cambodia-bound. Taking a boat trip to the Cham communities across the river or heading to nearby Sam Mountain and Tra Su Bird Sanctuary are other highlights, while the bustling market and intriguing waterfront provide fine backdrops to a few days of relaxation.

Northeast Vietnam includes Halong Bay, one of the region's biggest draws. Reasons to linger after your boat trip include the lesser-known but stunning Bai Tu Long Bay, the intersection of nature and culture that is Ba Be National Park, the otherworldly karst landscapes outside of Cao Bang and the urban options in Haiphong.

The epicentre of the Mekong Delta, Can Tho is the largest city in the region and feels like a metropolis after a few days exploring the backwaters. As the political, economic, cultural and transportation centre of the Mekong Delta, it’s a buzzing town with a lively waterfront lined with sculpted gardens, an appealing blend of narrow backstreets and wide boulevards, and perhaps the greatest concentration of foreigners in the delta. It is also the perfect base for nearby floating markets, the major draw for tourists who come here to boat along the many canals and rivers leading out of town.

Fringed with white-sand beaches and with large tracts still cloaked in dense tropical jungle, Phu Quoc rapidly morphed from a sleepy island backwater to a must-visit beach escape for Western expats and sun-seeking tourists. Beyond the resorts lining Long Beach, rapid development beginning on the east coast and mega resorts in sight of Sao Beach, there's still ample room for exploration and escaping the sometimes littered waters. Dive the reefs, kayak in the bays, eat up the back-road kilometres on a motorbike or just lounge on the beach, followed by a massage and a fresh seafood dinner.

Ho Chi Minh City (HCMC) is Vietnam at its most dizzying: a high-octane city of commerce and culture that has driven the country forward with its pulsating energy. A chaotic whirl, the city breathes life and vitality into all who settle here, and visitors cannot help but be hauled along for the ride.

Rugged, craggy and jungle-clad Cat Ba, the largest island in Halong Bay, has experienced a tourism surge in recent years. The central hub of Cat Ba Town is now framed by a chain of low-rise concrete hotels along its once-lovely bay, but the rest of the island is largely untouched and as wild as ever. With idyllic Lan Ha Bay just offshore, you'll soon overlook Cat Ba Town's overdevelopment.

Around 40km west of Danang lies lush Ba Na. Originally established in 1919 by the French as a hill resort, the 200-odd old villas are now ruined, but the refreshingly cool weather and gorgeous countryside views make it a worthwhile trip from Danang.