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Tra Vinh, one of the prettiest towns in the Mekong Delta, is a peaceful place to explore the region's little-touted Cambodian connection. Around 300,000 ethnic Khmer live in the surrounding province and the area is dotted with more than 140 Khmer pagodas. With wide boulevards shaded by lines of trees, the town itself is more symbolic of the French colonialist era, but get beyond the outskirts and you'll soon discover that Khmer culture is still alive and well in these parts of Vietnam. Tra Vinh also has a small but active Chinese community, one of the few such communities that remain in the Mekong Delta region.

This eponymous provincial capital isn't unpleasant; the climate is mild, and winter days can bring a chilly welcome relief from the heat when a thick fog clings to the banks of the Bang Giang River. But you'll most likely use the city as a base to explore rural Cao Bang province, one of the most beautiful regions in Vietnam.

Gateway to the Mekong Delta, My Tho is the capital of Tien Giang province and an important market town – although for the famous floating markets, you’ll need to continue on to Can Tho.

With its river setting and relatively traffic-free streets, relaxed Kon Tum makes a great stop for travelers intent on exploring the surrounding hill-tribe villages, of which there are 700 or so dotting the area – mostly Bahnar, but also Sedang and Jarai. This is a far better base than Pleiku for delving into indigenous culture, and there are a few intriguing sights in Kon Tum itself.

The site of Vietnam’s most extensive Cham remains, My Son enjoys an enchanting setting in a lush jungle valley, overlooked by Cat’s Tooth Mountain (Hon Quap). The temples are in poor shape – only about 20 structures survive where at least 68 once stood – but the intimate nature of the site, surrounded by gurgling streams, is still enthralling.

Once upon a time, Mui Ne was an isolated stretch of shoreline where pioneering travellers camped on the sand. Times have changed and it's now a string of beach resorts, which have fused into one long coastal strip. These resorts are, for the most part, mercifully low-rise and set amid pretty gardens by the sea. The original fishing village is still here, but tourists outnumber locals these days. There are a handful of luxury hotels (and a smattering of cheap guesthouses) but Mui Ne is mainly a midrange resort.

Draped along the banks of the Hau Giang River (Bassac River), Chau Doc sees plenty of travelers washing through on the river route between Cambodia and Vietnam. A likeable little town with significant Chinese, Cham and Khmer communities, Chau Doc's cultural diversity – apparent in the mosques, temples, churches and nearby pilgrimage sites – makes it fascinating to explore even if you're not Cambodia-bound. Taking a boat trip to the Cham communities across the river or heading to nearby Sam Mountain and Tra Su Bird Sanctuary are other highlights, while the bustling market and intriguing waterfront provide fine backdrops to a few days of relaxation.

Wow, the vistas. This is Vietnam's big-sky country; a place of rippling mountains, cascading rice terraces and the winnowed-out karst topography for which the region is famed.

Ho Chi Minh City (HCMC) is Vietnam at its most dizzying: a high-octane city of commerce and culture that has driven the country forward with its pulsating energy. A chaotic whirl, the city breathes life and vitality into all who settle here, and visitors cannot help but be hauled along for the ride.

Just off the Danang Beach coastal road, the Marble Mountains (Ngu Hanh Son) consist of five craggy marble outcrops topped with pagodas. Each mountain is named for the natural element it’s said to represent: Thuy Son (Water), Moc Son (Wood), Hoa Son (Fire), Kim Son (Metal or Gold) and Tho Son (Earth). The villages that have sprung up at the base of the mountains specialise in marble sculpture, though they now astutely use marble from China rather than hacking away at the mountains that bring the visitors in.