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Highlights of the Danang region include the city's impressive urban energy, the rapidly evolving beach scene to the east of the river, and more remote and spectacular coastal scenery of the nearby Son Tra Peninsula. Look forward to some of Vietnam's best seafood and street food. It's worth booking a walking tour with a local to best understand Danang.

Gateway to the Mekong Delta, My Tho is the capital of Tien Giang province and an important market town – although for the famous floating markets, you’ll need to continue on to Can Tho.

Northern Vietnam's most appealing city has a distinctly laid-back air with its tree-lined boulevards host to a bundle of colonial-era buildings. Caffeine-aficionado heaven, the central area buzzes with dinky cafes where tables spill out onto the pavements – perfect for people watching.

Practically obliterated during the American War, Vinh was rebuilt with East German aid – hence the brutalist concrete architecture dominating downtown. The only reasons to stop here are if you're a Ho Chi Minh devotee (he was born in a nearby village), or if you're heading to Laos.

Ha Tien may be part of the Mekong Delta, but lying on the Gulf of Thailand it feels a world away from the rice fields and rivers that typify the region. There are dramatic limestone formations peppering the area, which are home to a network of caves, some of which have been turned into temples. Plantations of pepper trees cling to the hillsides. On a clear day, Phu Quoc Island is easily visible to the west.

The epicentre of the Mekong Delta, Can Tho is the largest city in the region and feels like a metropolis after a few days exploring the backwaters. As the political, economic, cultural and transportation centre of the Mekong Delta, it’s a buzzing town with a lively waterfront lined with sculpted gardens, an appealing blend of narrow backstreets and wide boulevards, and perhaps the greatest concentration of foreigners in the delta. It is also the perfect base for nearby floating markets, the major draw for tourists who come here to boat along the many canals and rivers leading out of town.

Rugged, craggy and jungle-clad Cat Ba, the largest island in Halong Bay, has experienced a tourism surge in recent years. The central hub of Cat Ba Town is now framed by a chain of low-rise concrete hotels along its once-lovely bay, but the rest of the island is largely untouched and as wild as ever. With idyllic Lan Ha Bay just offshore, you'll soon overlook Cat Ba Town's overdevelopment.

Meo Vac is a small but charming district capital hemmed in by steep karst mountains and, like many towns in the northwest, it is steadily being settled by Vietnamese from elsewhere. The journey here along the spectacular Mai Pi Leng Pass, which winds for 22km from Dong Van, is the main attraction. The road has been cut into the side of a cliff with a view of rippling hills tumbling down to the distant waters of the Nho Que River far below. Right at the top of the pass is a lookout point where you can stop to take in the scenery.

Nowhere in Vietnam is changing as fast as Danang. For decades it had a reputation as a quiet provincial town, but big changes are ongoing. Stroll along the Han riverfront and you'll find gleaming new modernist hotels, and apartments and restaurants are emerging. Spectacular bridges now span the river, and in the north of the city, the landmark new D-City is rising from the flatlands. Venture south and the entire Danang Beach strip is booming with hotel and resort developments.

The spectacular karst limestone landscapes around Ninh Binh and Tam Coc are ideal for exploring by boat or bicycle, and there are stellar opportunities for caving and trekking amid the fast-developing travellers' scene of the Phong Nha-Ke Bang National Park. Dong Hoi, the coastal gateway to Phong Nha, also has an enjoyable low-key beach scene and good restaurants.