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Tra Vinh, one of the prettiest towns in the Mekong Delta, is a peaceful place to explore the region's little-touted Cambodian connection. Around 300,000 ethnic Khmer live in the surrounding province and the area is dotted with more than 140 Khmer pagodas. With wide boulevards shaded by lines of trees, the town itself is more symbolic of the French colonialist era, but get beyond the outskirts and you'll soon discover that Khmer culture is still alive and well in these parts of Vietnam. Tra Vinh also has a small but active Chinese community, one of the few such communities that remain in the Mekong Delta region.

Northern Vietnam's most appealing city has a distinctly laid-back air with its tree-lined boulevards host to a bundle of colonial-era buildings. Caffeine-aficionado heaven, the central area buzzes with dinky cafes where tables spill out onto the pavements – perfect for people watching.

A French-era hill station, this national park reaches a peak of 1450m at Bach Ma mountain, only 18km from the coast. The cool climate attracted the French, who built over a hundred villas here. Not surprisingly the Viet Minh tried hard to spoil the holiday – the area saw some heavy fighting in the early 1950s and again during the American War.

Isolated from the mainland, the Con Dao islands are one of Vietnam's star attractions. Long the preserve of political prisoners and undesirables, they now turn heads thanks to their striking natural beauty. Con Son, the largest of this chain of 15 islands and islets, is ringed with lovely beaches, coral reefs and scenic bays, and remains partially covered in tropical forests. In addition to hiking, diving and exploring deserted coastal roads there are excellent wildlife-watching opportunities, such as the black giant squirrel and endemic bow-fingered gecko.

Ha Tien may be part of the Mekong Delta, but lying on the Gulf of Thailand it feels a world away from the rice fields and rivers that typify the region. There are dramatic limestone formations peppering the area, which are home to a network of caves, some of which have been turned into temples. Plantations of pepper trees cling to the hillsides. On a clear day, Phu Quoc Island is easily visible to the west.

Cat Tien comprises an amazingly biodiverse area of lowland tropical rainforest. The 72,000-hectare park is one of the outstanding natural treasures in Vietnam, a true jungle, and the hiking, mountain biking and birdwatching here are the best in the south of the country. At weekends and public holidays it gets busy with domestic tourists – it's worth calling ahead to book the most popular excursions.

Highlights of this area include the vibrant city of Danang, the former imperial capital of Hue, and the very popular but undeniably stunning historic port town of Hoi An. The best beach scenes are at An Bang near Hoi An and Lang Co near Danang, and for nature fans there is good hiking and birdwatching in Bach Ma National Park. Ancient Cham history is fascinating at My Son, and the compelling Demilitarised Zone (DMZ) showcases the poignant and tragic stories of the American War.

Dien Bien Phu (DBP) plays a star role in Vietnam's modern history. It was in the surrounding countryside here, on 7 May 1954, that the French colonial forces were defeated by the Viet Minh in a decisive battle, and the days of their Indochina empire became numbered.

Once upon a time, Mui Ne was an isolated stretch of shoreline where pioneering travellers camped on the sand. Times have changed and it's now a string of beach resorts, which have fused into one long coastal strip. These resorts are, for the most part, mercifully low-rise and set amid pretty gardens by the sea. The original fishing village is still here, but tourists outnumber locals these days. There are a handful of luxury hotels (and a smattering of cheap guesthouses) but Mui Ne is mainly a midrange resort.

Northwest Vietnam, with its rocky, cone-like mountains, high vistas and deep valleys, encompasses some of the most extreme geography in the country – if not all of Southeast Asia. Travelling to the more remote parts of the region takes time and effort, but those short on either can stick around Sapa, the surrounding hills of which are a microcosm of the region as a whole.