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Set in an idyllic valley, hemmed in by hills, the Mai Chau area is a world away from Hanoi's hustle. The small town of Mai Chau itself is unappealing, but just outside the patchwork of rice fields rolls out, speckled by tiny Thai villages where visitors doss down for the night in traditional stilt houses and wake up to a rural soundtrack defined by gurgling irrigation streams and birdsong.

Plonked about midway between My Tho and Can Tho, Vinh Long is a major transit hub and the capital of the province. For travelers, it's a gateway to island life, Cai Be floating market, abundant orchards and rural homestays.

The high-rise, high-energy beach resort of Nha Trang enjoys a stunning setting: it's ringed by a necklace of hills, with a turquoise bay dotted with tropical islands.

The epicentre of the Mekong Delta, Can Tho is the largest city in the region and feels like a metropolis after a few days exploring the backwaters. As the political, economic, cultural and transportation centre of the Mekong Delta, it’s a buzzing town with a lively waterfront lined with sculpted gardens, an appealing blend of narrow backstreets and wide boulevards, and perhaps the greatest concentration of foreigners in the delta. It is also the perfect base for nearby floating markets, the major draw for tourists who come here to boat along the many canals and rivers leading out of town.

Draped along the banks of the Hau Giang River (Bassac River), Chau Doc sees plenty of travelers washing through on the river route between Cambodia and Vietnam. A likeable little town with significant Chinese, Cham and Khmer communities, Chau Doc's cultural diversity – apparent in the mosques, temples, churches and nearby pilgrimage sites – makes it fascinating to explore even if you're not Cambodia-bound. Taking a boat trip to the Cham communities across the river or heading to nearby Sam Mountain and Tra Su Bird Sanctuary are other highlights, while the bustling market and intriguing waterfront provide fine backdrops to a few days of relaxation.

Heading east of Hoi An, new housing and hotels mix with older rice paddies, and the riverbank meanders for around 5km to sandy beaches. This palm-fringed coastline extends north to Danang, and despite the development, there are still a few quieter stretches; it's a good area to explore independently on two wheels.

A popular weekend escape from HCMC, Vung Tau rocks at weekends when beach-starved locals and expats descend in numbers, but it is relatively quiet during the week. The city enjoys a spectacular location on a peninsula, with ocean on three sides; the light and sea air make it a refreshing break from sultry Saigon.

The ‘rice bowl’ of Vietnam, the delta is carpeted in a dizzying variety of greens. It's a water world that moves to the rhythms of the mighty Mekong, where boats, houses and markets float upon the innumerable rivers, canals and streams that criss-cross the landscape like arteries.

Lang Co is an attractive island-like stretch of palm-shaded white sand, with a turquoise lagoon on one side and 10km of beachfront on the other. As a beach resort it's more geared to Vietnamese day trippers than Western travellers, but if the weather's nice the ocean is certainly inviting (if you stay away from the central section, which could be cleaner). High season is April to July. From late August to November rains are frequent, and from December to March it can get chilly.

With limestone outcrops amid serene rice paddies, Tam Coc is best appreciated on a languorous rowing-boat ride, with the soundtrack of the river lapping against the oars.