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Ha Tien may be part of the Mekong Delta, but lying on the Gulf of Thailand it feels a world away from the rice fields and rivers that typify the region. There are dramatic limestone formations peppering the area, which are home to a network of caves, some of which have been turned into temples. Plantations of pepper trees cling to the hillsides. On a clear day, Phu Quoc Island is easily visible to the west.

Buon Ma Thuot can trace its origins back to a simple rural settlement: the Ede name translates as ‘Thuot’s father’s village’. But Buon Ma Thuot (pronounced ‘boon me tote’) has long outgrown its rustic origins and is now a thoroughly modern, affluent city.

The epicentre of the Mekong Delta, Can Tho is the largest city in the region and feels like a metropolis after a few days exploring the backwaters. As the political, economic, cultural and transportation centre of the Mekong Delta, it’s a buzzing town with a lively waterfront lined with sculpted gardens, an appealing blend of narrow backstreets and wide boulevards, and perhaps the greatest concentration of foreigners in the delta. It is also the perfect base for nearby floating markets, the major draw for tourists who come here to boat along the many canals and rivers leading out of town.

Northeast Vietnam includes Halong Bay, one of the region's biggest draws. Reasons to linger after your boat trip include the lesser-known but stunning Bai Tu Long Bay, the intersection of nature and culture that is Ba Be National Park, the otherworldly karst landscapes outside of Cao Bang and the urban options in Haiphong.

Dong Hoi is a pleasantly untouristed port and seaside town. It enjoys an attractive location, clinging to the banks of the Nhat Le River, and has beaches to the north and south. Recently established air links to Haiphong (for Halong Bay and Cat Ba Island) and the northern Thai city of Chiang Mai promise to significantly increase the city's appeal as a destination. Dong Hoi also has excellent transport links to the Phong Nha region.

With its river setting and relatively traffic-free streets, relaxed Kon Tum makes a great stop for travelers intent on exploring the surrounding hill-tribe villages, of which there are 700 or so dotting the area – mostly Bahnar, but also Sedang and Jarai. This is a far better base than Pleiku for delving into indigenous culture, and there are a few intriguing sights in Kon Tum itself.

The spectacular karst limestone landscapes around Ninh Binh and Tam Coc are ideal for exploring by boat or bicycle, and there are stellar opportunities for caving and trekking amid the fast-developing travellers' scene of the Phong Nha-Ke Bang National Park. Dong Hoi, the coastal gateway to Phong Nha, also has an enjoyable low-key beach scene and good restaurants.

Often referred to as the Ba Be Lakes, Ba Be National Park was established as a national park in 1992. The scenery here swoops from limestone mountains peaking at 1554m down into plunging valleys wrapped in dense evergreen forests, speckled with waterfalls and caves, with the lakes themselves dominating the very heart of the park.

Ha Giang is the final frontier in northern Vietnam, an amazing landscape of limestone pinnacles and granite outcrops. The far north of the province has some of the most spectacular scenery in the country – if not the region – and the trip between Yen Minh and Dong Van, and then across the Mai Pi Leng Pass to Meo Vac, is quite mind-blowing. Ha Giang should be one of the most popular destinations in this region, but its distance from just about everywhere else keeps visitor numbers at a low level.

Meo Vac is a small but charming district capital hemmed in by steep karst mountains and, like many towns in the northwest, it is steadily being settled by Vietnamese from elsewhere. The journey here along the spectacular Mai Pi Leng Pass, which winds for 22km from Dong Van, is the main attraction. The road has been cut into the side of a cliff with a view of rippling hills tumbling down to the distant waters of the Nho Que River far below. Right at the top of the pass is a lookout point where you can stop to take in the scenery.