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Ho Chi Minh City (HCMC) is Vietnam at its most dizzying: a high-octane city of commerce and culture that has driven the country forward with its pulsating energy. A chaotic whirl, the city breathes life and vitality into all who settle here, and visitors cannot help but be hauled along for the ride.

Graceful, historic Hoi An is Vietnam’s most atmospheric and delightful town. Once a major port, it boasts the grand architecture and beguiling riverside setting that befits its heritage, and the 21st-century curses of traffic and pollution are almost entirely absent.

The bustling port city of Phan Thiet is traditionally known for its nuoc mam (fish sauce), producing millions of liters of the stuff per annum. There's not much to see in town, but the riverside fishing harbor is always chock-a-block with brightly-painted boats and there are sights nearby including the Ke Ga lighthouse and Ta Cu Mountain.

This eponymous provincial capital isn't unpleasant; the climate is mild, and winter days can bring a chilly welcome relief from the heat when a thick fog clings to the banks of the Bang Giang River. But you'll most likely use the city as a base to explore rural Cao Bang province, one of the most beautiful regions in Vietnam.

Plonked about midway between My Tho and Can Tho, Vinh Long is a major transit hub and the capital of the province. For travelers, it's a gateway to island life, Cai Be floating market, abundant orchards and rural homestays.

Highlights of this area include the vibrant city of Danang, the former imperial capital of Hue, and the very popular but undeniably stunning historic port town of Hoi An. The best beach scenes are at An Bang near Hoi An and Lang Co near Danang, and for nature fans there is good hiking and birdwatching in Bach Ma National Park. Ancient Cham history is fascinating at My Son, and the compelling Demilitarised Zone (DMZ) showcases the poignant and tragic stories of the American War.

Few parts of Vietnam stir the imagination with the lure of adventure quite like the highlands. The ribbon that is the Ho Chi Minh Hwy winds its scenic way past coffee plantations, pine-studded mountains, rice paddies with their wallowing buffalo, enormous reed-covered lakes and peaceful villages, laying down the challenge of a two-wheeled journey.

Meo Vac is a small but charming district capital hemmed in by steep karst mountains and, like many towns in the northwest, it is steadily being settled by Vietnamese from elsewhere. The journey here along the spectacular Mai Pi Leng Pass, which winds for 22km from Dong Van, is the main attraction. The road has been cut into the side of a cliff with a view of rippling hills tumbling down to the distant waters of the Nho Que River far below. Right at the top of the pass is a lookout point where you can stop to take in the scenery.

The epicentre of the Mekong Delta, Can Tho is the largest city in the region and feels like a metropolis after a few days exploring the backwaters. As the political, economic, cultural and transportation centre of the Mekong Delta, it’s a buzzing town with a lively waterfront lined with sculpted gardens, an appealing blend of narrow backstreets and wide boulevards, and perhaps the greatest concentration of foreigners in the delta. It is also the perfect base for nearby floating markets, the major draw for tourists who come here to boat along the many canals and rivers leading out of town.

Ninh Binh is a good base for exploring quintessentially Vietnamese limestone scenery. Few Western tourists head here, but many Vietnamese flock to nearby sights, including the nation’s biggest pagoda and the Unesco World Heritage–listed Trang An grottoes.